15 maj 2019 — response against the universal cancer antigen telomerase. Ultimovacs is performing a broad clinical development program with clinical trials in

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Skickas inom 2-5 vardagar. Köp boken Telomeres and Telomerase in Cancer (ISBN 9781603273060) hos Adlibris. Fri frakt. Telomerase is the enzyme synthesizing the specific DNA sequences found at the telomeres and is thus responsible for maintaining their lengths. Telomerase activity can be found in most tumor cells, implicating that an active telomerase seems to be a prerequisite for tumor growth.

Telomerase and cancer

Telomerase reactivation in these mice caused extension of telomeres, reduced DNA damage, reversed neurodegeneration, and improved the function of the testes, spleen, and intestines. Thus, telomere reactivation may have potential for treating age-related diseases in humans. Telomerase and Cancer The knowledge of the basic biology of telomeres and telomerase has yielded fundamental insights into both cancer prevention and cancer promotion. The powerful and complex impact of telomere dynamics in model organisms and humans reflects the crucial role of telomere function in processes of genomic instability, organ homeostasis, chronic diseases, aging, and tumorigenesis.

2021-04-14 · Telomerase is an important drug target for cancer. It is expressed in most tumours from virtually all types of cancers and is required for long-term maintenance of telomeres, which in turn is Pris: 2919 kr. Inbunden, 2003.

It is well known that a decreased expression or inhibited activity of telomerase in cancer cells is accompanied by an increased sensitivity to some drugs (e.g., doxorubicin, cisplatin, or 5-fluorouracil). However, the mechanism of the resistance resulting from telomerase alteration remains elusive. There are theories claiming that it might be associated with telomere shortening, genome

What patients and caregivers need to know about cancer, coronavirus, and COVID-19. Whether you or someone you love has cancer, knowing what to ex Telomerase does this by adding additional telomere sequences to the ends of your chromosomes.

This demonstrated a clear link between telomerase and cancer, showing that tumor cells used the enzyme to make themselves effectively immortal. Cancer cells typically have very short telomeres, but the connection between telomerase and cancer ensures that the telomeres remain long enough for the cell to keep replicating, allowing a tumor to grow.

@phdthesis{d531185d0bc7452a97d8ca02401a8bb0,. title = "Exposure, telomere length, and cancer risk",. abstract = "Telomeres are tandem repeats of We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis.

If scientists can learn how to stop telomerase, they might be able to fight cancer by making cancer cells age and die. In one experiment, researchers blocked telomerase activity in human breast and prostate cancer cells growing in the laboratory, prompting the tumor cells to die. Telomerase reactivation in these mice caused extension of telomeres, reduced DNA damage, reversed neurodegeneration, and improved the function of the testes, spleen, and intestines. Thus, telomere reactivation may have potential for treating age-related diseases in humans. Telomerase and Cancer The knowledge of the basic biology of telomeres and telomerase has yielded fundamental insights into both cancer prevention and cancer promotion. The powerful and complex impact of telomere dynamics in model organisms and humans reflects the crucial role of telomere function in processes of genomic instability, organ homeostasis, chronic diseases, aging, and tumorigenesis. Telomeres, Telomerase and Cancer An Endless Search to Target the Ends ABSTRACT Maintenance of functional telomeres, the highly complex nucleo-protein structures, at the end of linear eukaryotic chromosomes, appears to be essential for growth and survival of the cells.
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The known functions of telomerase in tumor cells include replenishing radiosensitivity in human breast cancer MCF-7 cells by regulating hTERT and cyclin D1.

The powerful and complex impact of telomere dynamics in model organisms and humans reflects the crucial role of telomere function in processes of genomic instability, organ homeostasis, chronic diseases, aging, and tumorigenesis. Telomerase therapy is not only unlikely to result in an increased risk of cancer but is likely to lower the risk of cancer compared to age-matched patients not treated with telomerase therapy. Review of available data suggests that cancer should not be considered a significant risk to patients undergoing telomerase therapy, but the actual outcome will require human trials.

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Telomeres, repetitive (TTAGGG) DNA–protein complexes at the ends of chromosomes, are crucial for the survival of cancer cells. They are maintained by an

In the large majority of cancer cells, telomere length is maintained by telomerase.